|
control |
PD |
prodromal |
p |
|
|
(N=161)
|
(N=505)
|
(N=395)
|
|
subjectAge_BL
|
60.2 ± 11.6
|
62.3 ± 9.6
|
62.7 ± 7.1
|
0.012
|
|
subjectSex
|
|
|
|
< 0.001
|
|
F
|
59 (36.6%)
|
198 (39.2%)
|
215 (54.4%)
|
|
|
M
|
102 (63.4%)
|
307 (60.8%)
|
180 (45.6%)
|
|
|
mds_updrs_part_i_summary_score
|
2.9 ± 3.1
|
6.6 ± 4.9
|
5.6 ± 4.5
|
< 0.001
|
|
mds_updrs_part_ii_summary_score
|
0.4 ± 1.0
|
6.4 ± 4.8
|
1.3 ± 2.5
|
< 0.001
|
|
mds_updrs_part_iii_summary_score
|
0.9 ± 1.9
|
20.8 ± 9.1
|
3.0 ± 4.2
|
< 0.001
|
|
code_upd2hy_hoehn_and_yahr_stage
|
|
|
|
< 0.001
|
|
0
|
160 (99.4%)
|
110 (21.8%)
|
378 (95.7%)
|
|
|
1
|
1 ( 0.6%)
|
163 (32.3%)
|
13 ( 3.3%)
|
|
|
2
|
0 ( 0.0%)
|
227 (45.0%)
|
4 ( 1.0%)
|
|
|
3
|
0 ( 0.0%)
|
5 ( 1.0%)
|
0 ( 0.0%)
|
|
|
geneticMutation
|
|
|
|
< 0.001
|
|
Absent
|
161 (100.0%)
|
349 (69.1%)
|
62 (15.7%)
|
|
|
GBA
|
0 ( 0.0%)
|
44 ( 8.7%)
|
166 (42.0%)
|
|
|
LRRK2
|
0 ( 0.0%)
|
112 (22.2%)
|
167 (42.3%)
|
|
|
has24
|
|
|
|
< 0.001
|
|
FALSE
|
155 (96.3%)
|
398 (78.8%)
|
372 (94.2%)
|
|
|
TRUE
|
6 ( 3.7%)
|
107 (21.2%)
|
23 ( 5.8%)
|
|
|
has48
|
|
|
|
< 0.001
|
|
FALSE
|
158 (98.1%)
|
469 (92.9%)
|
324 (82.0%)
|
|
|
TRUE
|
3 ( 1.9%)
|
36 ( 7.1%)
|
71 (18.0%)
|
|
|
|